ncRNA name | CD9 siRNA |
ncRNA Category | siRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Homo sapiens |
Tissues/Cell_line | normal adult human dermal microvascular endothelial cells (HMVECs) |
Methods | siRNA transfection, WST-8 assay, immunocytochemistry, TUNEL assay, immunoblot, siRNA injection |
Expression pattern | associated |
Functional description | Injecting CD9-specific small interfering RNA (siRNA-CD9) markedly inhibited HGF- or VEGF-induced subconjunctival angiogenesis in vivo. Furthermore, intravitreous injections of siRNA-CD9 or anti-CD9 antibodies were therapeutically effective for laser-induced retinal and choroidal neovascularization in mice, a representative ocular angiogenic disease model. |
PubMed ID | 21875571 |
Year | 2011 |
Title | Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.